Reference Ranges

A reference range table has been compiled to determine whether or not a drug level is Toxic, or falls within the Therapeutic range. Please note that these ranges can be affected by age, sex, general health, synergism with other compounds, and individual response. These ranges are meant as guidelines, not absolute rules.

Agent	Normal Range	Toxic Range
Acetaminophen	5-2 ug/ml	> 200 ug/ml 4 hrs. > 50 ug/ml 24 hrs.
Acetone	Undefined	>= 0.02 g/dl
Alprazolam (Xanax)	5-34 ng/ml	Undefined
Amikacin	15-25 ug/ml	Peak > 35 ug/ml Trough > 5 ug/ml
Amiodarone	0.5-2.5 ug/ml	> 2.5 ug/ml

Definitions:

Normal Therapeutic Range:

The concentration of a drug present in the blood, serum, or plasma following therapeutically effective dosages in humans.

Toxic Range:

The concentration of a drug present in blood, serum, or plasma that is associated with toxic symptoms in humans.

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Agent	Normal Range	Toxic Range
ACETAMINOPHEN (TYLENOL)	5-2 ug/ml	> 200 ug/ml 4 hr > 50ug/ml 24 hr
ACETONE	Undefined	>= 0.02 g%
ALPRAZOLAM (XANAX)	5-35 ng/ml	Undefined
AMIKACIN	15-25 ug/ml	Peak: > 35 ug/ml Trough:> 5 ug/ml
AMIODARONE	0.5-2.5 ug/ml	> 2.5 ug/ml
DESETHYLAMIODARONE	No Range
AMITRIPTYLINE + NORTRIPTYLINE	120-250 ng/ml	> 500 ng/ml
AMOBARBITAL	1-5 ug/ml	> 10 ug/ml
AMOXAPINE (ASENDIN)	15-75 ng/ml	> 200 ng/ml
BUPIVACAINE (MARCAINE)	1-4 ug/ml	> 4 ug/ml
BUTABARBITAL	1-10 ug/ml	> 10 ug/ml
BUTALBITAL	1-10 ug/ml	> 10 ug/ml
CAFFEINE	5-15 ug/ml	> 20 ug/ml
CARBAMAZEPINE (TEGRETOL)	4-12 ug/ml	> 15 ug/ml
CARISOPRODOL(SOMA) Meprobamate	No range 5-20 ug/ml	> 30 ug/ml > 30 ug/ml
CHLORAL HYDRATE (AS TRICHLOROETHANOL)	2-12 ug/ml	> 40 ug/ml
CHLORAMPHENICOL (CHLORMYCETIN)	Peak 10-20 ug/ml Trough < 5.0 ug/ml	> 25 ug/ml
CHLORDIAZEPOXIDE (LIBRIUM)	0.3-3.0 ug/ml	> 3 ug/ml
CHLORPROMAZINE (THORAZINE)	50-500 ng/ml	> 1000 ng/ml
CLOMIPRAMINE (ANAFRANIL)	100-400 ng/ml	Undefined
CLONAZEPAM (KLONOPIN)	15-70 ng/ml	> 80 ng/ml
CLORAZEPATE (TRANXENE) as Nordiazepam metabolite	0.1-0.8 ug/ml	Undefined
CYANIDE	< 5.0 ug/dl	> 50 ug/dl
CYCLOBENZAPRINE (FLEXERIL)	10-30 ng/ml	Undefined
DESIPRAMINE (NORPRAMIN)	50-300 ng/ml	> 500 ng/ml
DIAZEPAM (VALIUM) NORDIAZEPAM (metabolite)	0.10-1.50 ug/ml 0.10-0.50 ug/ml	> 2.0 ug/ml
DIGITOXIN	10-30 ng/ml	> 30 ng/ml
DIGOXIN	0.5-2.0 ng/ml	> 2 ng/ml
DIPHENHYDRAMINE (BENADRYL)	0.1-1.0 ug/ml	> 1.0 ug/ml
DISOPYRAMIDE (NORPACE)	2-5 ug/ml	> 7 ug/ml
DOXEPIN (SINEQUAN)	75-200 ng/ml	>500 ng/ml
ETHANOL	Legal Limit: 0.10 g%	> 0.20 g%
ETHCHLORVYNOL (PLACIDYL)	2-8 ug/ml	> 20 ug/ml
ETHOSUXIMIDE (ZARONTIN)	40-100 ug/ml	> 150 ug/ml
ETHOTOIN (PEGANONE)	15-50 ug/ml	> 50 ug/ml
ETHYLENE GLYCOL	None Detected	> 50 mg/dl
FLUCYTOSINE (5-FC) (ANCOBAN)	25-100 ug/ml	> 125 ug/ml
FLUOXETINE (PROZAC) NORFLUOXETINE	100-800 ng/ml 100-600 ng/ml	Undefined
FLURAZEPAM (DALMANE) DESALKYLFLURAZEPAM	0.5-30 ng/ml 30-150 ng/ml	> 200 ng/ml > 500 ng/ml
FLUPHENAZINE (PROLIXIN)	0.20-4.0 ng/ml	Undefined
GABAPENTIN (NEURONTIN)	4.0-16.0 ug/ml	Undefined
GENTAMICIN	Peak 4-10 ug/ml Trough <2 ug/ml	> 12 ug/ml > 2 ug/ml
GLUTETHIMIDE	2-8 ug/ml	> 10 ug/ml
HALDOL (HALOPERIDOL)	3.0-15.0 ng/ml	Undefined
IBUPROFEN	10-50 ug/ml	> 100 ug/ml
IMIPRAMINE + DESIPRAMINE	150-300 ng/ml	> 500 ng/ml
INDOMETHACIN	0.5-3.0 ug/ml	> 5 ug/ml
ISOPROPANOL	None Detected	> 0.01 g%
LAMOTRIGINE (LAMICTAL)	1-3 ug/ml	Undefined
LIDOCAINE	1-5 ug/ml	> 7 ug/ml
LORAZEPAM (ATIVAN)	50-240 ng/ml	> 300 ng/ml
LOXAPINE (LOXITANE)	5-30 ng/ml	Undefined
MAPROTILINE (LUDIOMIL)	180-300 ng/ml	Undefined
MEPERIDINE (DEMEROL)	0.2-8.0 ug/ml	> 2.0 ug/ml
MEPIVACAINE	2-5 ug/ml	> 8.0 ug/ml
MEPROBAMATE	5-20 ug/ml	> 30 ug/ml
MESORIDAZINE (SERENTIL)	100-1000 ng/ml	> 1000 ng/ml
METHAQUALONE	1-5 ug/ml	> 8.0 ug/ml
METHOTREXATE (HIGH DOSAGE THERAPY)	Undefined	> 5.0 uM 24h > 0.5 uM 48h
METHSUXIMIDE (CELONTIN) [AS METABOLITE NORMETHSUXIMIDE]	10-40 ug/ml	> 55 ug/ml
METHYPRYLON (NOLUDAR)	5-15 ug/ml	> 30 ug/ml
METOPROLOL (LOPRESOR)	10-150 ng/ml	Undefined
MEXILETINE (MEXITIL)	0.5-2.0 ug/ml	> 2.0 ug/ml
MIDAZOLAM (VERSED)	50-600 ng/ml	Undefined

Copyright © 1999 [Toxicology Associates, Inc.]. All rights reserved.
Revised: January 13, 2010