Reference Ranges

A reference range table has been compiled to determine whether or not a drug level is Toxic, or falls within the Therapeutic range. Please note that these ranges can be affected by age, sex, general health, synergism with other compounds, and individual response. These ranges are meant as guidelines, not absolute rules.














































































































































1


                                           

Agent

Normal Range

Toxic Range

Acetaminophen

5-2 ug/ml

> 200 ug/ml 4 hrs.

> 50 ug/ml 24 hrs.

Acetone

Undefined

>= 0.02 g/dl

Alprazolam (Xanax)

5-34 ng/ml

Undefined

Amikacin

15-25 ug/ml

Peak > 35 ug/ml

Trough > 5 ug/ml

Amiodarone

0.5-2.5 ug/ml

> 2.5 ug/ml

 

 

 

 

 

 

 

 

 

 

 

 

 

 

 



Definitions:

Normal Therapeutic Range:

The concentration of a drug present in the blood, serum, or plasma following therapeutically effective dosages in humans.

Toxic Range:

The concentration of a drug present in blood, serum, or plasma that is associated with toxic symptoms in humans.

NEXTarrowsrt.gif (3348 bytes)

Agent

Normal Range Toxic Range
ACETAMINOPHEN
(TYLENOL)
5-2 ug/ml > 200 ug/ml 4 hr
> 50ug/ml 24 hr
ACETONE Undefined >= 0.02 g%
ALPRAZOLAM
(XANAX)
5-35 ng/ml Undefined
AMIKACIN 15-25 ug/ml Peak: > 35 ug/ml
Trough:> 5 ug/ml
AMIODARONE 0.5-2.5 ug/ml > 2.5 ug/ml
DESETHYLAMIODARONE No Range
AMITRIPTYLINE +
NORTRIPTYLINE
120-250 ng/ml > 500 ng/ml
AMOBARBITAL 1-5 ug/ml > 10 ug/ml
AMOXAPINE
(ASENDIN)
15-75 ng/ml > 200 ng/ml
BUPIVACAINE
(MARCAINE)
1-4 ug/ml > 4 ug/ml
BUTABARBITAL 1-10 ug/ml > 10 ug/ml
BUTALBITAL 1-10 ug/ml > 10 ug/ml
CAFFEINE 5-15 ug/ml > 20 ug/ml
CARBAMAZEPINE
(TEGRETOL)
4-12 ug/ml > 15 ug/ml
CARISOPRODOL(SOMA)
Meprobamate
No range
5-20 ug/ml
> 30 ug/ml
> 30 ug/ml
CHLORAL HYDRATE
(AS TRICHLOROETHANOL)
2-12 ug/ml > 40 ug/ml
CHLORAMPHENICOL
(CHLORMYCETIN)
Peak 10-20 ug/ml
Trough
< 5.0 ug/ml
> 25 ug/ml
CHLORDIAZEPOXIDE
(LIBRIUM)
0.3-3.0 ug/ml > 3 ug/ml
CHLORPROMAZINE
(THORAZINE)
50-500 ng/ml > 1000 ng/ml
CLOMIPRAMINE
(ANAFRANIL)
100-400 ng/ml Undefined
CLONAZEPAM
(KLONOPIN)
15-70 ng/ml > 80 ng/ml
CLORAZEPATE
(TRANXENE)
as Nordiazepam metabolite
0.1-0.8 ug/ml Undefined
CYANIDE < 5.0 ug/dl > 50 ug/dl
CYCLOBENZAPRINE
(FLEXERIL)
10-30 ng/ml Undefined
DESIPRAMINE
(NORPRAMIN)
50-300 ng/ml > 500 ng/ml
DIAZEPAM (VALIUM)

NORDIAZEPAM (metabolite)
0.10-1.50 ug/ml

0.10-0.50 ug/ml
> 2.0 ug/ml
DIGITOXIN 10-30 ng/ml > 30 ng/ml
DIGOXIN 0.5-2.0 ng/ml > 2 ng/ml
DIPHENHYDRAMINE
(BENADRYL)
0.1-1.0 ug/ml > 1.0 ug/ml
DISOPYRAMIDE
(NORPACE)
2-5 ug/ml > 7 ug/ml
DOXEPIN
(SINEQUAN)
75-200 ng/ml >500 ng/ml
ETHANOL Legal Limit: 0.10 g% > 0.20 g%
ETHCHLORVYNOL
(PLACIDYL)
2-8 ug/ml > 20 ug/ml
ETHOSUXIMIDE
(ZARONTIN)
40-100 ug/ml > 150 ug/ml
ETHOTOIN
(PEGANONE)
15-50 ug/ml > 50 ug/ml
ETHYLENE GLYCOL None Detected > 50 mg/dl
FLUCYTOSINE (5-FC)
(ANCOBAN)
25-100 ug/ml > 125 ug/ml
FLUOXETINE
(PROZAC)


NORFLUOXETINE
100-800 ng/ml


100-600 ng/ml
Undefined
FLURAZEPAM
(DALMANE)

DESALKYLFLURAZEPAM
0.5-30 ng/ml


30-150 ng/ml
> 200 ng/ml


> 500 ng/ml
FLUPHENAZINE
(PROLIXIN)
0.20-4.0 ng/ml Undefined
GABAPENTIN
(NEURONTIN)
4.0-16.0 ug/ml Undefined
GENTAMICIN Peak 4-10 ug/ml
Trough <2 ug/ml
> 12 ug/ml
> 2 ug/ml
GLUTETHIMIDE 2-8 ug/ml > 10 ug/ml
HALDOL
(HALOPERIDOL)
3.0-15.0 ng/ml Undefined
IBUPROFEN 10-50 ug/ml > 100 ug/ml
IMIPRAMINE +
DESIPRAMINE
150-300 ng/ml > 500 ng/ml
INDOMETHACIN 0.5-3.0 ug/ml > 5 ug/ml
ISOPROPANOL None Detected > 0.01 g%
LAMOTRIGINE
(LAMICTAL)
1-3 ug/ml Undefined
LIDOCAINE 1-5 ug/ml > 7 ug/ml
LORAZEPAM
(ATIVAN)
50-240 ng/ml > 300 ng/ml
LOXAPINE
(LOXITANE)
5-30 ng/ml Undefined
MAPROTILINE
(LUDIOMIL)
180-300 ng/ml Undefined
MEPERIDINE
(DEMEROL)
0.2-8.0 ug/ml > 2.0 ug/ml
MEPIVACAINE 2-5 ug/ml > 8.0 ug/ml
MEPROBAMATE 5-20 ug/ml > 30 ug/ml
MESORIDAZINE
(SERENTIL)
100-1000 ng/ml > 1000 ng/ml
METHAQUALONE 1-5 ug/ml > 8.0 ug/ml
METHOTREXATE
(HIGH DOSAGE THERAPY)
Undefined > 5.0 uM 24h
> 0.5 uM 48h
METHSUXIMIDE
(CELONTIN)
[AS METABOLITE NORMETHSUXIMIDE]
10-40 ug/ml > 55 ug/ml
METHYPRYLON
(NOLUDAR)
5-15 ug/ml > 30 ug/ml
METOPROLOL
(LOPRESOR)
10-150 ng/ml Undefined
MEXILETINE
(MEXITIL)
0.5-2.0 ug/ml > 2.0 ug/ml
MIDAZOLAM
(VERSED)
50-600 ng/ml Undefined
 

Copyright 1999 [Toxicology Associates, Inc.]. All rights reserved.
Revised: January 13, 2010