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Pharmaceutically Prepared Drug Analysis

1. Verification

Analysis of a commercially or pharmaceutically prepared drug is an important task to determine if the drug prepared drug solution contains the correct concentration and type of drug.  The drug solution could be questionable if after administration, the individual is unresponsive to the medication. 

Toxicological testing of drugs is also available on other fluids other than the more common blood, serum, or urine, and solids. These include CSF, Stool, Saline, IV Solution, etc. Typical specimen requirements are minimum of 2 mls (liquid) and/or 2 gr (solid). If this is not available, we will work with what you provide us.  Most test can be done on a Stat basis. If available, please provide us with as much information as possible about the case (i.e. suspected drugs, amount, etc.).  Base fees for Corporate, Institution/Organization ONLY.

Any drug(s) not listed in this list that you wish to test, please call us at 614-459-2307 or email us at staydrugfree@toxassociates.com.

2. Stability Study

This is an important task to determine the length of drug stability so that drug disposable and inventory can be manage more efficiently.  This can be a great savings, especially in this times of economic hardships where wasting a good product can be reduced if not altogether avoided.

A drug study can be done in many ways.   As an example, University Hospital Pharmacy needs to determine the concentration of Morphine with an initial drug of concentration  of 50 mg/ml over a period of time say 6 months.  They decided to conduct this study, because of raised concerns of the disposal of Morphine, in which it is disposed after 48 hrs. at room temperature after it is prepared by the pharmacy technician.  The Pharmacy prepared over 5000, 100 ml solution of Morphine everyday, and out 5000 approximately 12 % or 600 solutions worth over $75,000.00 are disposed because of reduced concentration after 48 hrs., that may not be effective when administered.

The following is an example scenario for determining the length of time Morphine diminishes in concentration at 50 mg/ml every 5 days for 90 days.  The protocol calls for disposal of the drug solution when the concentration reduces to 10 %.

From the data below, the day at which the concentration is reduced by 10 % or 45 mg/ml is at 45 days.  So from this study, Mophine solution is good for 45 days.  A great savings for the Pharmacy in avoiding wasting a perfectly good solution.

Of course, the study can be done in any way that you feel is best for your facility.  We will try to accommodate your needs and work with you in your study.

Time  (day) Concentration
( mg/ml)
Time (day) Concentration
 (mg/ml)
Time (day) Concentration
(mg/ml)
0 50.0 45 45.1 90 25.2
5 49.8 50 44.7    
10 49.5 55 44.2    
15 49.2 60 43.5    
20 49.0 65 41.4    
25 49.0 70 38.5    
30 48.7 75 35.2    
35 48.3 80 33.0    
40 47.8 85 28.0    



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Test

Specimen Requirements

Method
Acetaminophen
(Tylenol)

1 ml min

GC/MS, GC-TSD

Amphetamine Screen

2 ml min

GC/MS, GC-TSD

Antidepressant Screen










2 ml min

Amitriptyline, Desipramine, Fluoxetine (Prozac), Doxepin, Cyclobenzaprine, Imipramine, Nortriptyline



GC/MS

GC-TSD


Amitriptyline
(Elavil)


2 ml min



GC/MS, GC-TSD

Barbiturates Screen

Qualitative

Quantitative

     Amobarbital
     Butalbital
     Pentobarbital
     Phenobarbital
     Pentothal
     Secobarbital



1 ml min



1 ml min
1.5 ml min
1 ml min
1 ml min
1 ml min
1 ml min


GC/MS, GC-TSD


GC-TSD
GC-TSD
GC-TSD
GC-TSD
GC-TSD
GC-TSD
Benzodiazepines Screen

Qualitative



5 ml. min

Alprazolam (Xanax), Diazepam (Valium), Chlordiazepoxide (Librium), Nordiazepam, Flurazepam (Dalmane), Temazepam, Oxazepam (Serax), Halcion, Halazepam


GC-TSD, GC/MS
Benzodiazepines

Quantitative

     Alprazolam
     Clonazepam
     Diazepam
     Flurazepam
     Flunitrazepam
     Librium
     Lorazepam
     Midazolam
     Temazepam




2 ml min
2 ml min
2 ml min
2 ml min
2 ml min
2 ml min
2 ml min
2 ml min
2 ml min




GC-ECD
GC-TSD
GC-TSD
GC-TSD
GC-TSD
GC-TSD
GC-ECD
GC-ECD
GC-TSD
Clonidine

Qualitative

Quantitative


2 ml min

2 ml min


GC/MS

GC-TSD
Cocaine



Qualitative


Quantitative
(if bodily fluid specimen, includes metabolites Benzoylecgonine & Methylecgonine)

2 ml min


3 ml min




GC/MS, GC-TSD

GC-TSD
Codeine



Qualitative


Quantitative
(if bodily fluid specimen, includes metabolites Morphine & Hydrocodone)

2 ml min


3 ml min




GC-TSD, GC/MS

GC-TSD
Cyanide

Qualitative/Quantitative

4 ml min SPEC
Cyclobenzaprine
(Flexeril)

Quantitative

Qualitative




2.5 ml min

3 ml min



GC-TSD

GC-TSD, GC/MS
Desipramine
(Norpramin)

Quantitative

Qualitative




2.5 ml min

3 ml min



GC-TSD

GC-TSD, GC/MS
Doxepin
(Sinequan)

Quantitative

Qualitative




2.5 ml min

2.0 ml min



GC-TSD

GC/MS
Ephedrine

Quantitative


Qualitative



2.5 ml min


2 ml min


GC-MS, GC-TSD

GC-TSD
Ethosuximide
(Zarontin)

Qualitative


Quantitative




2 ml min


2 ml min



GC/MS, GC-TSD

GC-TSD
Fluphenazine
(Antipsychotic) Qualitative

Quantitative



2 ml min.


3 ml min


GC/MS, GC-TSD

GC-TSD, GC-FID
Gabapentin
(Neurontin)

Qualitative


Quantitative



2 ml min


2 ml min



GC-MS, GC-TSD

GC-TSD, HPLC
Haldol
(Haloperidol)

Quantitative

Qualitative




3 ml min

2 ml min



GC-TSD

GC/MS, GC-TSD
Heroin
(Diacetylmorphine)

Qualitative


Quantitative



2 ml min


2.5 ml min



GC/MS, GC-TSD

GC-TSD, GC-FID
Hydrocodone
(Vicodin)

Qualitative


Quantitative



2 ml min


2 ml min



GC/MS, GC-TSD

GC-TSD
Hydromorphone
(Dilaudid)

Qualitative


Quantitative



2 ml min


2 ml min



GC-FID, GC/MS

GC/MS
Ibuprofen
(Motrin, Advil)

Qualitative


Quantitative



2 ml min.


1 ml min



GC/MS, GC-FID

GC/MS, HPLC, GC-FID
Imipramine
(Tofranil)

Qualitative


Quantitative



2 ml min


2.5 ml min



GC/MS, GC-FID

GC-TSD
Lamotrigine
(Lamictal)

Qualitative

Quantitative




2 ml min

2 ml min



GC/MS

HPLC
Lidocaine
(Xylocaine)

Quantitative


Qualitative



1 ml min


2 ml min



GC-TSD, GC-FID

GC/MS, GC-TSD
LSD
(Lysergic Diethylamide)

Quantitative


Qualitative



2 ml min


2 ml min



GC-TSD, SPEC

GC/MS, GC-TSD

Copyright 1999 [Toxicology Associates, Inc.]. All rights reserved.
Revised: January 13, 2010